EC Number   |
General Information  |
Reference |
|---|
   3.4.16.6 | malfunction |
absence of Kex1p diminishes HOCl-induced production of reactive oxygen species, apoptosis and protein modification |
731598 |
| 3.4.16.6 | malfunction |
kexA deletion strain shows slightly lower growth speed. Deletion strain exhibits scarcely branched hyphae, whereas an kexA-overexpressing strain exhibits a hyperbranching phenotype |
731176 |
| 3.4.16.6 | malfunction |
LNCap cells treated with CPD siRNA show a decreased NO production and cell viability, but increased apoptosis |
732850 |
| 3.4.16.6 | malfunction |
targeted reduction of CPD in Huh7 cells results in decreased growth and enhanced apoptosis of Huh 7 cells in vitro |
731593 |
| 3.4.16.6 | physiological function |
CpD is the only endogenous carboxypeptidase that cleaves antibody heavy chain C-terminal lysine in CHO cells. Knockdown of CpD by RNAi increases C-terminal lysine levels of antibodies, whereas there is no obvious change in C-terminal lysine levels when carboxypeptidase CpM, CpN, CpB, or CpE is knocked downIn a CpD knockout mutant, C-terminal lysine cleavage is completely abolished |
753046 |
| 3.4.16.6 | physiological function |
CPD-mediated production of nitrix oxide promotes the survival of LNCaP cells |
732850 |
| 3.4.16.6 | physiological function |
protease Kex1p mediates HOCl-induced lethality |
731598 |
