EC Number   |
General Information |
Reference  |
|---|
   2.7.1.173 | physiological function |
nicotinamide riboside kinase has an important role in the biosynthesis of NAD+ as well as the activation of tiazofurin and other nicotinamide riboside analogues for anticancer therapy |
682879 |
| 2.7.1.173 | metabolism |
nicotinamide riboside elevates NAD+ levels via the nicotinamide riboside kinase pathway and by a pathway initiated by splitting the nucleoside into a nicotinamide base followed by nicotinamide salvage. Yeast nicotinic acid riboside utilization largely depends on uridine hydrolase and nicotinamide riboside kinase, and nicotinic acid riboside bioavailability is increased by ester modification |
-, 698901 |
| 2.7.1.173 | more |
comparison to the Nrk-independent utilization pathway of nicotinamide riboside in yeast, overview |
-, 698901 |
| 2.7.1.173 | physiological function |
nicotinamide riboside kinase increases the NAD+ levels via convertion of the substrate nicotinamide riboside and thereby extending replicative lifespan and increases Sir2-dependent gene silencing |
-, 698901 |
| 2.7.1.173 | metabolism |
in addition to the seven-component pyridine nucleotide cycle, an eight-component cycle involving nicotinate riboside kinase operates in plants. NaR kinase does not make a significant contribution to salvage for pyridine nucleotide synthesis |
718225 |
| 2.7.1.173 | evolution |
the enzyme is structurally similar to Rossmann fold metabolite kinases |
718250 |
| 2.7.1.173 | metabolism |
the enzyme is involved in the eukaryotic nicotinamide riboside kinase, Nrk, pathway, which is induced in response to nerve damage and promotes replicative life span in yeast, converts nicotinamide riboside to NAD+ by phosphorylation and adenylylation, overview. Nicotinic acid riboside is utilized in vivo by Urh1, Pnp1, and Preiss-Handler salvage |
718250 |
| 2.7.1.173 | metabolism |
distinct metabolic routes, starting from various precursors, are known to support NAD+ biosynthesis with tissue/cell-specific efficiencies, probably reflecting differential expression of the corresponding rate-limiting enzymes, i.e. nicotinamide phosphoribosyltransferase, quinolinate phosphoribosyltransferase, nicotinate phosphoribosyltransferase and nicotinamide riboside kinase |
738213 |
| 2.7.1.173 | physiological function |
nicotinamide riboside is a relevant NAD+ precursor |
738213 |
| 2.7.1.173 | malfunction |
in NRK1-silenced cells, both nicotinamide riboside- and NMN-mediated rescue from FK866-induced NAD+ depletion and cell death are potently and significantly reduced, overview |
739212 |
