EC Number   |
General Information |
Reference |
|---|
   2.7.1.173 | more |
comparison to the Nrk-independent utilization pathway of nicotinamide riboside in yeast, overview |
-, 698901 |
| 2.7.1.173 | metabolism |
distinct metabolic routes, starting from various precursors, are known to support NAD+ biosynthesis with tissue/cell-specific efficiencies, probably reflecting differential expression of the corresponding rate-limiting enzymes, i.e. nicotinamide phosphoribosyltransferase, quinolinate phosphoribosyltransferase, nicotinate phosphoribosyltransferase and nicotinamide riboside kinase |
738213 |
| 2.7.1.173 | metabolism |
in addition to the seven-component pyridine nucleotide cycle, an eight-component cycle involving nicotinate riboside kinase operates in plants. NaR kinase does not make a significant contribution to salvage for pyridine nucleotide synthesis |
718225 |
| 2.7.1.173 | malfunction |
in NRK1-silenced cells, both nicotinamide riboside- and NMN-mediated rescue from FK866-induced NAD+ depletion and cell death are potently and significantly reduced, overview |
739212 |
| 2.7.1.173 | metabolism |
nicotinamide riboside elevates NAD+ levels via the nicotinamide riboside kinase pathway and by a pathway initiated by splitting the nucleoside into a nicotinamide base followed by nicotinamide salvage. Yeast nicotinic acid riboside utilization largely depends on uridine hydrolase and nicotinamide riboside kinase, and nicotinic acid riboside bioavailability is increased by ester modification |
-, 698901 |
| 2.7.1.173 | physiological function |
nicotinamide riboside is a relevant NAD+ precursor |
738213 |
| 2.7.1.173 | physiological function |
nicotinamide riboside kinase has an important role in the biosynthesis of NAD+ as well as the activation of tiazofurin and other nicotinamide riboside analogues for anticancer therapy |
682879 |
| 2.7.1.173 | physiological function |
nicotinamide riboside kinase increases the NAD+ levels via convertion of the substrate nicotinamide riboside and thereby extending replicative lifespan and increases Sir2-dependent gene silencing |
-, 698901 |
| 2.7.1.173 | physiological function |
NRK2 appears to play a redundant role in NAD+ biosynthesis along with NRK1, at least in unchallenged models, its highly regulated expression particularly in times of stress suggest it may have role beyond NAD+ metabolism |
761705 |
| 2.7.1.173 | more |
proposed NRK expression in disease and potential therapeutic interventions |
761705 |
