EC Number   |
General Information |
Reference  |
|---|
    2.6.1.13 | metabolism |
OAT plays a different role in arginine, ornithine and proline metabolism depending on the tissue and their physiological needs |
703993 |
| 2.6.1.13 | metabolism |
catalyzes step 5 in the ornithine fermentation pathway |
704292 |
| 2.6.1.13 | physiological function |
enzyme is implicated in salt tolerance in higher plants, enzyme is implicated in proline biosynthesis and accumulation via pyrroline-5-carboxylate |
706356 |
| 2.6.1.13 | physiological function |
enzyme is implicated in salt tolerance in higher plants, enzyme is implicated in proline biosynthesis and accumulation via pyrroline-5-carboxylate, OAT is essential for nitrogen recycling from arginine but not for the stress-induced proline accumulation, OAT probably links the degradation pathways for arginine and proline |
706356 |
| 2.6.1.13 | malfunction |
the influence of OAT activity in a model of septic shock induced by intraperitoneal injection of lipopolysaccharide in wild-type and transgenic mice overexpressing OAT in the liver, kidney and intestine is analysed. OAT overexpression has only limited metabolic consequences, most probably because of compensatory mechanisms ensuring amino acid homeostasis. OAT overexpression brings a metabolic advantage in the response to stress. Results show an inhibition of OAT activity and expression in the liver following LPS treatment |
721263 |
| 2.6.1.13 | physiological function |
increased OAT activity and ornithine concentration can impact the supply of substrates for proline synthesis |
723051 |
| 2.6.1.13 | malfunction |
deltaOAT and proline dehydrogenases (ProDH1 and ProDH2) are involved in the defence against non-host pathogens. Mutants for these genes compromise non-host resistance and show a decrease in non-host pathogen-induced reactive oxygen species |
723382 |
| 2.6.1.13 | malfunction |
deltaOAT and proline dehydrogenases (ProDH1 and ProDH2) are involved in the defence against non-host pathogens. Silencing of these genes in Nicotina benthamiana delays occurrence of hypersensitive response and favours non-host pathogen growth |
723382 |
| 2.6.1.13 | physiological function |
deltaOAT is involved in effector-triggered immunity (ETI) and plays a critical role in inducing early oxidative burst and other defence pathways in plants, conceivably by accumulating P5C in mitochondria |
723382 |
| 2.6.1.13 | physiological function |
ornithine-delta-aminotransferase OAT is essential for Xenopus embryonic development, and overexpression of OAT produces a ventralized phenotype characterized by a small head, lack of axial structure, and defective expression of neural developmental markers. Substitution of both Arg 180 and Leu 402 abrogates both OAT enzymatic activity and ability to modulate the developmental phenotype. Neurogenesis is inhibited by OAT during Xenopus embryonic development |
738432 |
