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Results 1 - 10 of 11 > >>
EC Number
General Information
Commentary
Reference
malfunction
deltaOAT and proline dehydrogenases (ProDH1 and ProDH2) are involved in the defence against non-host pathogens. Mutants for these genes compromise non-host resistance and show a decrease in non-host pathogen-induced reactive oxygen species
malfunction
deltaOAT and proline dehydrogenases (ProDH1 and ProDH2) are involved in the defence against non-host pathogens. Silencing of these genes in Nicotina benthamiana delays occurrence of hypersensitive response and favours non-host pathogen growth
malfunction
the influence of OAT activity in a model of septic shock induced by intraperitoneal injection of lipopolysaccharide in wild-type and transgenic mice overexpressing OAT in the liver, kidney and intestine is analysed. OAT overexpression has only limited metabolic consequences, most probably because of compensatory mechanisms ensuring amino acid homeostasis. OAT overexpression brings a metabolic advantage in the response to stress. Results show an inhibition of OAT activity and expression in the liver following LPS treatment
metabolism
catalyzes step 5 in the ornithine fermentation pathway
metabolism
OAT plays a different role in arginine, ornithine and proline metabolism depending on the tissue and their physiological needs
physiological function
deltaOAT is involved in effector-triggered immunity (ETI) and plays a critical role in inducing early oxidative burst and other defence pathways in plants, conceivably by accumulating P5C in mitochondria
physiological function
enzyme is implicated in salt tolerance in higher plants, enzyme is implicated in proline biosynthesis and accumulation via pyrroline-5-carboxylate
physiological function
enzyme is implicated in salt tolerance in higher plants, enzyme is implicated in proline biosynthesis and accumulation via pyrroline-5-carboxylate, OAT is essential for nitrogen recycling from arginine but not for the stress-induced proline accumulation, OAT probably links the degradation pathways for arginine and proline
physiological function
in the presence of arginine, Mycobacterium tuberculosis upregulates a gene cluster which includes ornithine aminotransferase (rocD) and Rv2323c, a gene of up to now unknown function. In Mycobacterium tuberculosis, arginine is not only used as nitrogen source but also as carbon source for the formation of amino acids, in particular of proline. RocD is naturally deleted in Mycobacterium tuberculosis, but not in non-tuberculous mycobacteria. Mycobacterium tuberculosis lacking gene Rv2323c shows a growth defect on arginine, does not produce proline from arginine, and incorporates less nitrogen derived from arginine in its core nitrogen metabolism
physiological function
increased OAT activity and ornithine concentration can impact the supply of substrates for proline synthesis
Results 1 - 10 of 11 > >>