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General Information
the enzyme catalyzes the first step of the dimethylsulfoniopropionate, DMSP, cleavage pathway. DMSP is a ubiquitous phytoplankton metabolite that is degraded by marine microorganisms by at least two major pathways
DmdA belongs to a diverse family of enzymes, the overall fold of the DmdA is not similar to other enzymes that typically utilize the reduced form of tetrahydrofolate and in fact is a triple domain structure similar to what has been observed for the glycine cleavage T protein or sarcosine oxidase. All other THF binding fold enzymes produce 5,10-methylene-tetrahydrofolate. The relative positioning of Y206 in DmdA is different in comparison to the other THF dependent enzymes
phylogenetic analysis, multidimensional analysis based on the abundances of dimethylsulfoniopropionate degradation genes and environmental factors reveal that the distribution pattern of these genes is influenced by chlorophyll a concentrations and temperatures. dddP genes, dmdA subclade C/2 genes, and dmdA subclade D genes exhibit significant correlations with the marine Roseobacter clade, SAR11 subgroup Ib, and SAR11 subgroup Ia, respectively. SAR11 subgroups Ia and Ib, which possess dmdA genes, are suggested to be the main potential dimethylsulfoniopropionate consumers
physiological function
DMSP demethylase is responsible for the dimethylsulfoniopropionate assimilation
detection of taxon-specific gene expression in Roseobacter sp. HTCC2255 and in situ regulation of the first gene in each DMSP pathway, gene dddP and gene dmdA, that corresponds with shifts in the taxonomy of the phytoplankton community
the bacterial switch is a proposed regulatory point in the global sulfur cycle that routes dimethylsulfoniopropionate to two fundamentally different fates in seawater through genes encoding either the cleavage or demethylation pathway, and affects the flux of volatile sulfur from ocean surface waters to the atmosphere
positive correlation of katG expression with gene dmdA but not gene dddP during the period when regulation expression is uncoupled
Results 1 - 7 of 7