EC Number |
General Information |
Reference |
---|
1.14.18.5 | malfunction |
deleting the SUR2 gene reduces hydroxylation of ceramides and suppresses Ca2+ sensitivity of csg2 mutants |
719792 |
1.14.18.5 | malfunction |
yeast strains deficient in Syr2 lack the sphingoid long chain base phytosphingosine |
-, 719795 |
1.14.18.5 | physiological function |
C-4 hydroxylation of sphingolipids is important for the antifungal action of syringomycin E. Mutants with defects in C-4 hydroxylated sphingoid base biosynthesis are resistant to this antifungal agent |
733375 |
1.14.18.5 | physiological function |
sphingolipid C4 hydroxylation by the enzyme influences properties of detergent-insoluble glycolipid-enriched membranes |
719486 |
1.14.18.5 | physiological function |
Sur2p is required for the hydroxylation of C-4 of the sphingoid moiety of ceramide. The enzyme is not essential for growth |
719792 |
1.14.18.5 | physiological function |
SYR2 is necessary for growth inhibition by the cyclic lipodepsipeptide syringomycin E. The SYR2 gene is required for the 4-hydroxylation reaction of sphingolipid long chain bases and is not essential for growth. SYR2 does not play a role in sterol biosynthesis |
-, 719795 |
1.14.18.5 | physiological function |
the enzyme plays an essential role in phytosphingolipid synthesis in human skin and other phytosphingolipid-containing tissues |
719485 |