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Results 1 - 7 of 7
EC Number
General Information
Commentary
Reference
malfunction
deleting the SUR2 gene reduces hydroxylation of ceramides and suppresses Ca2+ sensitivity of csg2 mutants
malfunction
yeast strains deficient in Syr2 lack the sphingoid long chain base phytosphingosine
physiological function
C-4 hydroxylation of sphingolipids is important for the antifungal action of syringomycin E. Mutants with defects in C-4 hydroxylated sphingoid base biosynthesis are resistant to this antifungal agent
physiological function
sphingolipid C4 hydroxylation by the enzyme influences properties of detergent-insoluble glycolipid-enriched membranes
physiological function
Sur2p is required for the hydroxylation of C-4 of the sphingoid moiety of ceramide. The enzyme is not essential for growth
physiological function
SYR2 is necessary for growth inhibition by the cyclic lipodepsipeptide syringomycin E. The SYR2 gene is required for the 4-hydroxylation reaction of sphingolipid long chain bases and is not essential for growth. SYR2 does not play a role in sterol biosynthesis
physiological function
the enzyme plays an essential role in phytosphingolipid synthesis in human skin and other phytosphingolipid-containing tissues
Results 1 - 7 of 7