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Results 1 - 7 of 7
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General Information
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metabolism
CYP7B1 is an enzyme expressed in many human tissues and implicated in cholesterol metabolism. In the liver, this protein is part of the alternate/acidic pathway for primary bile acid production while in brain, CYP7B1 provides the primary metabolic route for cholesterol derivatives dehydroepiandrosterone and related hydroxysteroids via 7alpha-hydroxylation
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spastic paraplegia type 5, SPG5, is caused by mutations in CYP7B1, a gene encoding the cytochrome P-450 oxysterol 7-alpha-hydroxylase, CYP7B1, an enzyme implicated in cholesterol metabolism. Mutations in CYP7B1 are found in both pure and complicated forms of the disease, clinical phenotypes, overview
physiological function
activity towards 5alpha-androstane-3alpha,17beta-diol is very low or undetectable in livers of Cyp7b1(-/-) knockout mice. CYP7B1-mediated catalysis may play a role for control of the cellular levels of androgens, not only of estrogens
physiological function
CYP7B1-mediated catalysis may play a role for control of the cellular levels of androgens, not only of estrogens
physiological function
important role for CYP7B1 in cellular growth, particularly in connection with estrogenic signalling
physiological function
key enzyme in bile acid synthesis by the alternative pathway
physiological function
pregnane X receptor activation significantly regulates genes in the liver involved in lipoprotein transportation and cholesterol metabolism, including CYP39A1, in both wild-type and ApoE-/- mice
Results 1 - 7 of 7