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Results 1 - 6 of 6
EC Number General Information Commentary Reference
Show all pathways known for 1.13.11.79Display the reaction diagram Show all sequences 1.13.11.79physiological function enzyme deletion mutant is unable to convert Mg-protoporphyrin IX monomethyl ester into protochlorophyllide, mutant starin grows poorly under anoxic photoheterotrophic conditions 689775
Show all pathways known for 1.13.11.79Display the reaction diagram Show all sequences 1.13.11.79physiological function a Tn5 insertion mutant is unable to grow in minimal media and fails to establish a symbiosis with alfalfa. Effect can be rescued by addition of vitamin B12 or of 5,6-dimethylbenzimidazole. Mutant does not produce cobalamin unless 5,6-dimethylbenzimidazole is supplied 706482
Show all pathways known for 1.13.11.79Display the reaction diagram Show all sequences 1.13.11.79more identification of catalytic residues involved in the reaction, mutational analysis, overview. The enzyme shows interactions with the phosphate group and ribityl tail of FMN 728760
Show all pathways known for 1.13.11.79Display the reaction diagram Show all sequences 1.13.11.79metabolism BluB/CobT2 is the crucial enzyme in the B12 biosynthetic pathway of Propionibacterium freudenreichii -, 745700
Show all pathways known for 1.13.11.79Display the reaction diagram Show all sequences 1.13.11.79physiological function the enzyme is involved in production of vitamin B12, a prerequisite for attempts to naturally fortify foods with B12 by microbial fermentation. Active vitamin B12 is distinguished from the pseudovitamin by the presence of 5,6-dimethylbenzimidazole (DMBI) as the lower ligand. Fusion enzyme BluB/CobT2 is efficient in metabolite channeling, and the enzymes' inability to react with adenine, a lower ligand present in the pseudovitamin, reveals a mechanism favoring the production of the active form of the vitamin, requirement of oxygen for DMBI synthesis, since the organism does not synthesize cobalamin. BluB is responsible for the formation of DMBI from FMNH2 in the presence of oxygen, BluB/CobT2 activates DMBI into alpha-RP in the presence of NaMN -, 745700
Show all pathways known for 1.13.11.79Display the reaction diagram Show all sequences 1.13.11.79metabolism the enzyme gene is required for aerobic 5,6-dimethylbenzimidazole synthesis for cobalamin production 764756
Results 1 - 6 of 6