EC Number   |
General Information  |
Reference |
|---|
    1.1.2.4 | malfunction |
under methylglyoxal treatment, silencing of OsD-LDH in rice results in the accumulation of methylglyoxal and D-lactate, the decrease of reduced glutathione in leaves, and ultimately severe growth inhibition. The silencing of OsD-LDH does not affect the growth under photorespiration conditions |
-, 763102 |
| 1.1.2.4 | metabolism |
prostate cancer cells metabolize D-lactate inside mitochondria via a D-lactate dehydrogenase which is more active and highly expressed than in normal cells. D-Lactate can enter prostate mitochondria and cause the export of newly synthesized malate in a carrier-mediated manner, with the rate of malate efflux from mitochondria being twofold higher in cancer compared to healthy cells, overview |
740447 |
| 1.1.2.4 | metabolism |
the enzyme participates in methylglyoxal metabolism by affecting the activity of the glyoxalase system and aldoketo reductases |
-, 763102 |
| 1.1.2.4 | physiological function |
participates in the methylglyoxal pathway |
698932 |
| 1.1.2.4 | physiological function |
the mitochondrial D-lactate dehydrogenase, a membrane flavoprotein, from both cancer (PC-3) and normal (PNT1A) prostate cells can metabolize D-lactate in an energy competent manner |
740447 |
| 1.1.2.4 | physiological function |
transgenic plants overexpressing both D-LDH and cytochrome c have enhanced capacity to detoxify D-lactate and methylglyoxal, indicating that both proteins can be limiting factors in the detoxification process |
743500 |
