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General Information
prostate cancer cells metabolize D-lactate inside mitochondria via a D-lactate dehydrogenase which is more active and highly expressed than in normal cells. D-Lactate can enter prostate mitochondria and cause the export of newly synthesized malate in a carrier-mediated manner, with the rate of malate efflux from mitochondria being twofold higher in cancer compared to healthy cells, overview
physiological function
participates in the methylglyoxal pathway
physiological function
the mitochondrial D-lactate dehydrogenase, a membrane flavoprotein, from both cancer (PC-3) and normal (PNT1A) prostate cells can metabolize D-lactate in an energy competent manner
physiological function
transgenic plants overexpressing both D-LDH and cytochrome c have enhanced capacity to detoxify D-lactate and methylglyoxal, indicating that both proteins can be limiting factors in the detoxification process
Results 1 - 4 of 4