EC Number   |
General Information |
Reference |
|---|
    5.4.4.2 | metabolism |
the bifunctional salicylate synthase converts chorismate into salicylate through a two-step reaction, exhibiting both isochorismate synthase (EC 5.4.4.2) and isochorismate lyase (EC 4.2.99.21) activities |
748448 |
| 5.4.4.2 | metabolism |
the enzyme produces isochorismate for conversion to salicylate by isochorismate-pyruvate lyase, PchB, and incorporation into the pyochelin siderophore. Isochorismate synthase (PchA) and isochorismate-pyruvate lyase (PchB) from Pseudomonas aeurginosa are involved in the synthesis of the siderophore pyochelin |
726963 |
| 5.4.4.2 | metabolism |
the first committed step during the biosynthesis of siderophores, which are small molecules capable of chelating iron from the host organism, is the conversion of chorismate into isochorismate by isochorismate synthase (EC 5.4.4.2) and consequently to salicylate by isochorismate pyruvate-lyase (EC 4.2.99.21). Salicylate synthase converts chorismate into salicylate through a two-step reaction |
747617 |
| 5.4.4.2 | metabolism |
the first committed step during the biosynthesis of siderophores, which are small molecules capable of chelating iron from the host organism, is the conversion of chorismate into isochorismate by isochorismate synthase (EC 5.4.4.2) and consequently to salicylate by isochorismate pyruvate-lyase (EC 4.2.99.21). the bifunctional salicylate synthase converts chorismate into salicylate through a two-step reaction, exhibiting both isochorismate synthase (EC 5.4.4.2) and isochorismate lyase (EC 4.2.99.21) activities |
-, 747617 |
| 5.4.4.2 | more |
enzyme structure comparisons and analysis, active site structure, overview. Ala304 plays an important role in positioning the peptide-bond carbonyl, enabling the formation of a proper hydrogen bond to the isochorismate C2 hydroxyl |
-, 726636 |
| 5.4.4.2 | more |
enzyme three-dimensional structure analysis, the lysine residue, Lys190, might be involved in the activation of water molecules and the subsequent nucleophilic attack on the C2 carbon of chorismate without directly involving the magnesium ion, participation of the Lys residue during the activation of the substrate or nucleophilic agent |
747617 |
| 5.4.4.2 | more |
homology modeling of isozymes ICS1 and ICS2 using Serratia marcescens anthranilate synthase (TrpE, PDB ID 1I7Q) as reference structure |
747030 |
| 5.4.4.2 | more |
solvent kinetic isotope effects, overview |
726817 |
| 5.4.4.2 | more |
structure-function relationships of chorismate-utilizing enzymes, structure comparisons, overview. Isochorismate synthase cannot perform any pericyclic reaction. Residues K221 and E269 are general base and acid, respectively |
726963 |
| 5.4.4.2 | physiological function |
Arabidopsis ICS1 represents a divergent isoform for inducible salicylic acid synthesis during defense |
706530 |
