EC Number |
General Information |
Reference |
---|
3.4.22.55 | physiological function |
caspase-2 modulates osteoclastogenesis through down-regulating oxidative stress |
731559 |
3.4.22.55 | physiological function |
caspase-2 plays a critical role in mediating the synaptic changes and memory alteration induced by amyloid beta in Alzheimer's disease |
732560 |
3.4.22.55 | physiological function |
caspase-2 plays a role in lipoapoptosis and is required for cell death |
732099 |
3.4.22.55 | physiological function |
caspase-2 plays important roles in stress-induced apoptosis, cell cycle regulation, and tumor suppression |
717846 |
3.4.22.55 | physiological function |
caspases-2 and -8 are involved in the presenilin1/gamma-secretase-dependent cleavage of amyloid precursor protein after the induction of apoptosis |
709626 |
3.4.22.55 | physiological function |
critical role of caspase-2 in mediating rough Brucella abortus induced macrophage cell death |
713348 |
3.4.22.55 | physiological function |
discussion of the role of caspase-2 and potential contribution of the enzyme to the pathology of human diseases |
712556 |
3.4.22.55 | physiological function |
in epithelial cells, caspase-2 is activated as an initiator caspase in a PIDDosome-independent manner to regulate pore-forming toxin-mediated cell death |
731596 |
3.4.22.55 | physiological function |
overview on the function of caspase-2 in cell death signaling |
711697 |
3.4.22.55 | physiological function |
role of caspase-2 in apoptosis, and caspase-2 may act as a tumor suppressor, mechanisms through which caspase-2 signals, e.g. involving PIDD, also known as LRDD or leucine-rich repeat and death domain-containing protein, caspase-2 pathways to apoptosis and cell cycle arrest, detailed overview. PIDD activation and more importantly caspase-2 activation is not always synonymous with induction of apoptosis, a threshold of caspase-2 activation must be reached before caspase-2-dependent apoptosis is engaged. Cleavage of Mdm2 is not the sole way caspase-2 can induce growth arrest |
717458 |