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EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.55physiological function caspase-2 modulates osteoclastogenesis through down-regulating oxidative stress 731559
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.55physiological function caspase-2 plays a critical role in mediating the synaptic changes and memory alteration induced by amyloid beta in Alzheimer's disease 732560
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.55physiological function caspase-2 plays a role in lipoapoptosis and is required for cell death 732099
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.55physiological function caspase-2 plays important roles in stress-induced apoptosis, cell cycle regulation, and tumor suppression 717846
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.55physiological function caspases-2 and -8 are involved in the presenilin1/gamma-secretase-dependent cleavage of amyloid precursor protein after the induction of apoptosis 709626
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.55physiological function critical role of caspase-2 in mediating rough Brucella abortus induced macrophage cell death 713348
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.55physiological function discussion of the role of caspase-2 and potential contribution of the enzyme to the pathology of human diseases 712556
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.55physiological function in epithelial cells, caspase-2 is activated as an initiator caspase in a PIDDosome-independent manner to regulate pore-forming toxin-mediated cell death 731596
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.55physiological function overview on the function of caspase-2 in cell death signaling 711697
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.55physiological function role of caspase-2 in apoptosis, and caspase-2 may act as a tumor suppressor, mechanisms through which caspase-2 signals, e.g. involving PIDD, also known as LRDD or leucine-rich repeat and death domain-containing protein, caspase-2 pathways to apoptosis and cell cycle arrest, detailed overview. PIDD activation and more importantly caspase-2 activation is not always synonymous with induction of apoptosis, a threshold of caspase-2 activation must be reached before caspase-2-dependent apoptosis is engaged. Cleavage of Mdm2 is not the sole way caspase-2 can induce growth arrest 717458
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