EC Number   |
General Information |
Reference |
|---|
   3.4.22.53 | physiological function |
calpain-1 and calpain-2 play opposite roles in retinal ganglion cell death induced by acute intraocular pressure elevation. Calpain-1 activity supports survival of retinal ganglion cell after intraocular pressure elevation. Calpain-2 activity promotes cell death of retinal ganglion cells after intraocular pressure elevation. Calpain-2 activation cleaves striatal-enriched protein tyrosine phosphatase and activates STEP-mediated pro-death pathway in retinal ganglion cells after intraocular pressure elevation |
754896 |
| 3.4.22.53 | physiological function |
calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes |
717806 |
| 3.4.22.53 | physiological function |
calpain-2 is crucial for promotion of migration and metastasis by caspase-8 |
707980 |
| 3.4.22.53 | physiological function |
calpain-2 is involved in cell motility |
707365 |
| 3.4.22.53 | physiological function |
m-calpain antagonizes RhoA overactivation and endothelial barrier dysfunction under disturbed shear conditions |
708018 |
| 3.4.22.53 | physiological function |
m-calpain translocates during ischemia and activates at reperfusion in isolated rat hearts |
709566 |
| 3.4.22.53 | physiological function |
m-calpain up-regulates alpha- and beta-actin in alveolar rhabdomyosarcoma cells |
708416 |
| 3.4.22.53 | physiological function |
mitochondrial m-calpain is associated with ERp75 and plays an important role in releasing of truncated apoptosis-inducing factor from mitochondria |
707281 |
| 3.4.22.53 | physiological function |
mitochondrial m-calpain plays a role in the release of truncated apoptosis-inducing factor from the mitochondria by cleaving voltage-dependent anion channel |
707559 |
| 3.4.22.53 | physiological function |
the Ca2+-dependent release of m-calpain from the mitochondrial outer membrane has important implications in facilitating apoptotic cell death |
717157 |
