EC Number   |
General Information |
Reference |
|---|
   3.4.22.53 | malfunction |
short interfering RNA-induced silencing of m-calpain results in increased RhoA activity and hyperpermeability in the aortic arch, which is accompanied by ROCK inhibitor-sensitive phosphorylation of downstream effecter LIM kinase 2, stress fibre accumulation in endothelium and enhanced interendothelial gaps |
708018 |
| 3.4.22.53 | malfunction |
the blockage of calpain 2 suppresses p38 MAPK phosphorylation |
709241 |
| 3.4.22.53 | malfunction |
the knockdown of calpain 2 significantly reduces cord formation, adhesion, and migration of human lymphatic microvascular dermal-derived endothelial cells on Matrigel compared to the control |
731892 |
| 3.4.22.53 | metabolism |
calpain 2 regulates endothelial nitric oxide synthase phosphorylation during cord formation by lymphatic endothelial cells on Matrigel |
731892 |
| 3.4.22.53 | metabolism |
isoform-specific hyperactivation of calpain-2, but not calpain-1 occurs at the synapse early in the pathogenesis of Alzheimer's disease potentially contributing to the deregulation of synaptic signaling in Alzheimer's disease |
755493 |
| 3.4.22.53 | metabolism |
MARCKS protein i.e. myristoylated alanine-rich C kinase substrate is a substrate of calpain-2 in the presence of Ca2+. Calpain-2 proteolysis of MARCKS promotes its interaction with lipids and ENaC at the plasma membrane to allow for the phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent regulation of epithelial sodium channel (ENaC) activity in the kidney |
752437 |
| 3.4.22.53 | metabolism |
nuclear translocation of calpain-2 mediates apoptosis of hypertrophied cardiomyocytes in transverse aortic constriction rat. Angiotensin II enhances the interaction between activated calpain-2 and Ca2+/calmodulin-dependent protein kinase II deltaB (CaMKIIdB), and promotes the degradation of CaMKIIdB by calpain-2 in the nuclei of hypertrophied cardiomyocytes. The depressed CaMKIIdeltaB downregulates the expression of antiapoptotic Bcl-2 leading to mitochondrial depolarization and release of cytochrome c which leads to apoptosis of hypertrophied cardiomyocytes |
754244 |
| 3.4.22.53 | physiological function |
an endoplasmic reticulum stress-related calpain-down-regulated PPAR-gamma/HO-1 pathway is involved in the interleukin-13-enhanced activated death of microglia |
708062 |
| 3.4.22.53 | physiological function |
Ca2+ overload induces apoptosis, which was correlated with calpain-2 activation |
708389 |
| 3.4.22.53 | physiological function |
calpain 2 activation is an early event in heat stress-induced male germ cell apoptosis |
709241 |
