EC Number   |
General Information |
Reference |
|---|
   3.4.21.B30 | physiological function |
the umuD gene products are upregulated after DNA damage and play roles in both nonmutagenic and mutagenic aspects of the SOS response |
-, 752775 |
| 3.4.21.B30 | physiological function |
The umuD gene products perform distinct functions in preventing and facilitating mutagenesis. The full-length dimeric UmuD2 is the initial product that is expressed shortly after the induction of the SOS response and inhibits bacterial mutagenesis, allowing for error-free repair to occur. The slow auto-cleavage of UmuD2 to UmuD'2 promotes mutagenesis to ensure cell survival. The intracellular levels of UmuD2 and UmuD?2 are further regulated by degradation in vivo, returning the cell to a nonmutagenic state. Dynamic regulatory roles of the umuD gene, overview. UmuD lifecycle involves dimer exchange and cleavage in the regulation of the DNA damage respons |
-, 731345 |
| 3.4.21.B30 | physiological function |
UmuD is a dynamic protein that regulates mutagenesis. The UmuD gene products, regulated by the SOS response, exist in two principal forms: UmuD2, which prevents mutagenesis, and UmuD2, which facilitates UV-induced mutagenesis. UmuD slows the resumption of DNA replication after UV irradiation. UmuD interacts with DinB and inhibits its mutagenic -1 frameshift activity. UmuD2 interacts with the RecA/ssDNA filament, which stimulates the ability of UmuD to cleave itself |
718023 |
| 3.4.21.B30 | physiological function |
UmuD is implicated in a primitive DNA damage checkpoint and prevents DNA polymerase IV-dependent -1 frameshift mutagenesis, while the cleaved form UmuD' facilitates UmuC-dependent mutagenesis via formation of DNA polymerase V (UmuD'2C). Thus, the cleavage of UmuD is a crucial switch that regulates replication and mutagenesis via numerous protein-protein interactions. |
709543 |
| 3.4.21.B30 | physiological function |
UmuD regulates the cellular response to DNA damage |
717851 |
| 3.4.21.B30 | physiological function |
UmuD2 is the initial umuD gene product that appears after induction of the SOS response. It is involved in regulating mutagenesis as part of the tightly controlled SOS response |
718102 |
| 3.4.21.B30 | physiological function |
UmuD2, when bound to DinB, displaces the equilibrium in favor of the non-slipped conformation, thereby preventing frameshifting and potentially enhancing DinB activity on non-slipped substrates. DinB template slippage is inhibited by UmuD2 |
709122 |
| 3.4.21.B30 | physiological function |
when bound to UmuC, the enzyme functions as a checkpoint in delaying cell division, allowing time for error-free repair mechanisms to act, error-prone polymerase accessory UmuD. UmuD is not required for UmuDAb expression from its native promoter, nor its disappearance after DNA damage through intermolecular interactions with Escherichia coli UmuD |
731823 |
