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<< < Results 11 - 15 of 15
EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.2.2.6physiological function in cultured macrophages, lipopolysaccharide LPS can upregulate CD38 expression in time- and dose-dependent manner. Knocking down or blockade of CD38 in macrophages inhibits LPS-induced macrophage M1 polarization accompanied by diminished NF-kappaB signaling activation. In a mouse model with LPS-induced acute kidney injury, blocking CD38 with quercetin significantly relieves kidney dysfunction, kidney pathological changes as well as inflammatory cell accumulation 750282
Display the word mapDisplay the reaction diagram Show all sequences 3.2.2.6physiological function leukocyte antigen CD38 expression is an early marker of all-trans retinoic acid-stimulated differentiation in the leukemic cell line HL-60 where CD38 promotes induced myeloid maturation when overexpressed. The ability of CD38 to propel all-trans retinoic acid-induced myeloid differentiation and G1/0 arrest is unimpaired by loss of its ectoenzymeactivity 714921
Display the word mapDisplay the reaction diagram Show all sequences 3.2.2.6physiological function senescent cells do not have high expression of CD38. The senescent associated secretory phenotype factors secreted by senescent cells induce CD38 mRNA and protein expression and increase CD38-NADase activity in non-senescent cells such as endothelial cells or bone marrow derived macrophages 749830
Display the word mapDisplay the reaction diagram Show all sequences 3.2.2.6physiological function the enzyme is a signaling enzyme responsible for catalyzing the synthesis of cyclic ADP ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate, both are universal Ca2+ messenger molecules 731296
Display the word mapDisplay the reaction diagram Show all sequences 3.2.2.6physiological function the enzyme is CD38-cADPR signaling system in frog cells 732501
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