EC Number   |
General Information |
Reference |
|---|
    2.6.1.13 | malfunction |
toxic effect of elevated intraocular concentrations of ornithine and its metabolites in excess, such as spermine, on the retinal pigment epithelial cells, together with Pro deficiency in the choroid and retina |
758876 |
| 2.6.1.13 | malfunction |
transgenic plants overexpressing TaOAT show enhanced tolerance to drought stress by increasing proline accumulation. In addition, salt tolerance of the transgenic plants is also enhanced |
758976 |
| 2.6.1.13 | malfunction |
transgenic plants overexpressing TaOAT show enhanced tolerance to drought stress by increasing proline accumulation. In addition, salt tolerance of the transgenic plants is also enhanced. The TaOAT-5AL-1 gene transcript variant contains in-frame stop codon that causes the incomplete translation of protein |
758976 |
| 2.6.1.13 | metabolism |
catalyzes step 5 in the ornithine fermentation pathway |
704292 |
| 2.6.1.13 | metabolism |
OAT plays a different role in arginine, ornithine and proline metabolism depending on the tissue and their physiological needs |
703993 |
| 2.6.1.13 | metabolism |
the expression of the genes involved in the arginine operon (argCJBDFGH) for the control of the L-ornithine biosynthesis pathway that is regulated through the binding of ArgR to the so-called ARG operator sites preceding those relevant target genes |
-, 756237 |
| 2.6.1.13 | metabolism |
the ornithine delta-transaminase, OAT, stands at the crossroads of several metabolic pathways. The role of enzyme OAT in ornithine fluxes, overview |
758876 |
| 2.6.1.13 | metabolism |
the PLP-dependent enzyme is involved in the interconversion of ornithine and glutamyl-5-semialdehyde (GSA) |
758976 |
| 2.6.1.13 | more |
the presence of Val79 in the active site of TgOAT in place of Tyr, as in its human counterpart, provides the necessary room to accommodate N-acetylornithine and GABA, resembling the active site arrangement of GABA transaminases. Contribution of active site Val79 to the specificity of the TgOAT enzym. The crystal structure of TgOAT in its internal aldimine form (PDB ID 4ZLV) is used to generate a structrue model of the V79Y mutant enzyme form, molecular modelling |
-, 758756 |
| 2.6.1.13 | physiological function |
deltaOAT is involved in effector-triggered immunity (ETI) and plays a critical role in inducing early oxidative burst and other defence pathways in plants, conceivably by accumulating P5C in mitochondria |
723382 |
