EC Number |
General Information |
Reference |
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2.3.1.135 | malfunction |
vitamin A uptake from recombinant holo-retinol-binding protein exhibited by wild-type mice is impaired in Lrat-deficient mice. Lrat-/- mice show elevated cellular vitamin A-binding protein 1, CRBP1, protein in the liver, lung, and adipose tissue as compared with wild type control animals |
-, 720030 |
2.3.1.135 | physiological function |
lecithin:retinol acyltransferase is critical for cellular uptake of vitamin A from serum retinol-binding protein, which depends on functional coupling of STRA6 with intracellular lecithin:retinol acyltransferase. Vitamin A uptake is regulated by all-trans-retinoic acid in nonocular tissues of mice. When in excess, vitamin A is rapidly taken up and converted to its inert ester form in peripheral tissues, such as lung, whereas in vitamin A deficiency, ocular retinoid uptake is favored |
-, 720030 |
2.3.1.135 | physiological function |
lecithin:retinol acyltransferase, LRAT, is a membrane-bound protein that plays an essential function in the visual cycle. It catalyzes the esterification of retinol into retinyl esters in the retinal pigment epithelium as well as in other tissues including testis, liver, and intestine |
720353 |
2.3.1.135 | physiological function |
downregulation of LRAT expression in rat hepatic stellate cells is required for mobilization of retinyl ester in liver injury for tissue repair and wound healing, interleukin-1 is a potent suppressor of LRAT with a hierarchy role in the transcriptional regulation, interleukin-1 does not regulate the stability of LRAT protein. Interleukin-1 is a key mediator to down-regulate LRAT in liver injury |
720839 |
2.3.1.135 | physiological function |
quiescent LRAT knockout hepatic stellate cells retain the capacity to synthesize retinyl esters and to store neutral lipids in lipid droplets ex vivo. The median lipid droplet size in LRAT knockout hepatic stellate cells (1080 nm) is significantly smaller than in wild-type stellate cells (1618 nm). Upon prolonged (24h) incubation, the amounts of small (less than 700 nm) lipid droplets strongly increases both in wild type and in LRAT knockout hepatic stellate cells |
756085 |
2.3.1.135 | physiological function |
cellular retinol-binding protein CRBP I effectively conveys retinol to the LRAT, thereby circumventing the low enzymatic activity of LRAT in polar bear livers |
758200 |
2.3.1.135 | physiological function |
retinoid isomerohydrolase RPE65 palmitoylation level is highly regulated by lecithin:retinol acyltransferase (LRAT) enzyme. In the presence of LRAT substrate all-trans retinol, there is a significant decrease in the level of palmitoylation of RPE65 |
758452 |