EC Number   |
General Information |
Reference |
|---|
    1.1.1.37 | malfunction |
exposure of maize plants to excess concentrations of Zn2+ and Cu2+ in the hydroponic solution inhibited lateral root growth, decreased malate dehydrogenase activity and changed isoform profiles |
-, 723482 |
| 1.1.1.37 | malfunction |
in a flo16 knockout mutant, the transition from sucrose to starch is partially disrupted during mutant grain filling |
762119 |
| 1.1.1.37 | malfunction |
in glucose minimal medium, the DELTAndh mutant, but not the DELTAldhA and DELTAmdh strains, show reduced growth and a lowered NAD+/NADH ratio. Growth of the double mutants DELTAndh/DELTAmdh and DELTAndh/DELTAldhA, but not of strain DELTAmdh/DELTAldhA, in glucose medium is stronger impaired than that of the DELTAndh mutant. In L-lactate minimal medium the DELTAndh mutant grows better than the wild-type. The DELTAndh/DELTAmdh mutant fails to grow in L-lactate medium and acetate medium. Growth with L-lactate can be restored by additional deletion of sugR. Ndh, Mdh and LdhA together cannot be replaced by other NADH-oxidizing enzymes in Corynebacterium glutamicum |
-, 761123 |
| 1.1.1.37 | malfunction |
knockdown of MDH1 in young human dermal fibroblasts and the IMR90 human fibroblast cell line results in the appearance of significant cellular senescence features, including senescence-associated beta-galactosidase staining, flattened and enlarged morphology, increased population doubling time, and elevated p16INK4A and p21CIP1 protein levels. The NAD/NADH ratio is decreased by 90% in MDH1 knockdown dermal fibroblasts but only by about 30% in MDH2 knockdown dermal fibroblasts |
723540 |
| 1.1.1.37 | metabolism |
in Leuconostoc mesenteroides strain ATCC 8293, which lacks an L-ldh gene, L-lactate is produced through sequential enzymatic conversions from phosphoenolpyruvate to oxaloacetate, then L-malate, and finally L-lactate by phosphoenolpyruvate carboxylase (PEPC, gene ppcA, UniProt ID Q03VI7, LEUM_1694), L-MDH, and malolactic enzyme (MLE, UniProt ID Q03XG6, LEUM_1005), respectively |
-, 748018 |
| 1.1.1.37 | metabolism |
isoform MDH1 generates malate with carbons derived from glutamine, thus enabling utilization of glucose carbons for glycolysis and for biomass |
762064 |
| 1.1.1.37 | metabolism |
isoform MDH3 is an essential component of the gluconeogenesis pathway that generates glucose from noncarbohydrate carbon substrates and is involved in the reoxidation of NADH produced by fatty-acid beta-oxidation in glyoxysomes |
760295 |
| 1.1.1.37 | metabolism |
malate dehydrogenase utilizes NAD/NADH as coenzyme to reversibly catalyze the oxidation/reduction of the malate/oxaloacetate. The mitochondrial isoenzyme (mMDH) catalyzes the oxidation of malate, and is the last step of the citric acid cycle, while the cytoplasmic isoenzyme (cMDH) primarily reduces oxaloacetate in the cytoplasm |
740165, 740166 |
| 1.1.1.37 | metabolism |
the enzyme gene FLO16 plays a critical role in redox homeostasis that is important for compound starch grain formation and subsequent starch biosynthesis in rice endosperm |
762119 |
| 1.1.1.37 | metabolism |
the enzyme is involved in the Krebs cycle (catabolism), glyoxylate and Hatch-Slack cycles, and malate metabolism, as well as other anabolic processes |
739892 |
