    7.1.2.2 | down |
repression of beta-F1-ATPase expression in development and in cancer, translational silencing is usually mediated by 3'UTR-mediated sequestration of the mRNA into RNPs. Role of ATPase inhibitor factor 1 and of Ras-GAP SH3 binding protein 1, G3BP1, controlling the activity of the H+-ATP synthase and the translation of beta-F1-ATPase mRNA respectively in cancer cells. A trans-acting factor that regulate beta-F1-ATPase mRNA translation, is G3BP1, Ras-GAP SH3 binding protein 1, that interacts with the 3'UTR of beta-mRNA, the interaction specifically represses mRNA translation by preventing its recruitment into active polysomes |
718971 |
