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EC Number	Expression	Commentary	Reference
4.2.1.75	down	branchpoint sequence mutation markedly reduces the wild type transcript and enzyme activity	702860
4.2.1.75	down	the efficiency of Uros gene suppression is developmentally regulated, being most effective in mature seedling leaves compared with newly emergent leaves	706223
4.2.1.75	up	the hepatic and splenic URO-synthase activities are normal or elevated (1-1.6fold) compared with age and sex-matched feline control activities in the dominantly inherited acute intermittent porphyria lines	703965

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Release 2023.1 (January 2023)