EC Number   |
Expression |
Reference |
|---|
    4.1.2.27 | down |
enzyme expression is down-regulated in rice plants after treatments with salicylic acid, benzothiadiazole and 1-amino cyclopropane-1-carboxylic acid |
748935 |
| 4.1.2.27 | down |
SGPL1 gene expression is downregulated in colon cancer and is upregulated in certain malignant tissues, for example, in ovarian cancers as well as in the skin of patients suffering from atopic dermatitis |
716860 |
| 4.1.2.27 | up |
basal SPL activity is low in wild type cardiac tissue but is activated 3fold in response to 50 min of ischemia |
713721 |
| 4.1.2.27 | up |
enzyme expression is increased in brains of patients with Alzheimer's disease |
746682 |
| 4.1.2.27 | up |
enzyme expression is induced by infection with a virulent strain of Magnaporthe oryzae |
748935 |
| 4.1.2.27 | up |
high SPL transcription of H1155 cells is regulated by specificity protein 1 and GATA-4 protein/specificity protein 1 complex formation |
714336 |
| 4.1.2.27 | up |
mRNA expression for both sphingosine kinase and sphingosine 1-phosphate lyase are up-regulated throughout all four stages in human breast cancer patients. Exogenous administration of S1P produces a bell-shaped dose response for apoptosis in normal mammary gland MCF12A cells but a sigmoid-shaped apoptotic response in breast cancer MCF7 cells. Co-administration of S1P enhances the cytotoxicity of anticancer drug docetaxel against MCF7 cells |
708817 |
