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Results 1 - 10 of 15 > >>
EC Number Expression Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.79down enzyme expression is decreased in natural killer cells following immunosuppressive therapy 731864
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.79down serine protease inhibitor A3N, i.e. serpin A3N or SA3N, an extracellular inhibitor of GrB possessing multiple biological functions, including the attenuaxadtion of muscular dystrophy in mice, neuropathic pain, and GrB-mediated decorin cleavage and rupture. It also induces neuroprotection in vitro and in vivo. Role of GrB inhibitor SA3N on Escherichia coli LPS-induced inflammation in NK-92 cells. SA3N pretreatment prevents the LPS-induced changes in expression levels of GRP78, CHOP, NF-kappaB and IkappaBalpha proteins. Also SA3N pretreatment prevents the expression and exocytosis of GrB by LPS 754761
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.79down treatment of regulatory T cells (Tregs) with the mammalian target of rapamycin (mTOR) inhibitor, rapamycin or the PI3 kinase (PI3K) inhibitor LY294002 markedly suppresses granzyme B expression 707882
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.79up expression of granzyme B is higher in patients with Bronchiolitis obliterans syndrome than in patients with acute lung transplant rejection 708189
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.79up expression of GrB mRNA is upregulated in active lesions of multiple sclerosis patients and in activated T cells 717943
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.79up extracellular levels of the enzyme are elevated in the bodily fluids in chronic inflammatory diseases such as atherosclerosis and rheumatoid arthritis 732687
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.79up GrB expression in plasmacytoid dendritic cells is strictly regulated on a transcriptional level involving Janus kinase 1 (JAK1), signal transducer and activator of transcription 3 (STAT3), and STAT5. Interleukin-3 (IL-3), secreted by activated T cells, plays a central role for GrB induction 707852
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.79up GrB in urothelial cancer tissues is concentrated at the cancer invasion front and is expressed in neoplastic cells undergoing epithelial-mesenchymal transition, a key event in carcinoma invasion 708765
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.79up IL-21 directly induces GzmB expression and secretion by CD51 B cells 708381
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.79up in blood, bronchoalveolar lavage (BAL) and large airway brushing expression of granzyme B is significantly increased in lung transplant patients 708189
Results 1 - 10 of 15 > >>