EC Number |
Expression |
Reference |
---|
3.4.21.79 | down |
enzyme expression is decreased in natural killer cells following immunosuppressive therapy |
731864 |
3.4.21.79 | down |
serine protease inhibitor A3N, i.e. serpin A3N or SA3N, an extracellular inhibitor of GrB possessing multiple biological functions, including the attenuaxadtion of muscular dystrophy in mice, neuropathic pain, and GrB-mediated decorin cleavage and rupture. It also induces neuroprotection in vitro and in vivo. Role of GrB inhibitor SA3N on Escherichia coli LPS-induced inflammation in NK-92 cells. SA3N pretreatment prevents the LPS-induced changes in expression levels of GRP78, CHOP, NF-kappaB and IkappaBalpha proteins. Also SA3N pretreatment prevents the expression and exocytosis of GrB by LPS |
754761 |
3.4.21.79 | down |
treatment of regulatory T cells (Tregs) with the mammalian target of rapamycin (mTOR) inhibitor, rapamycin or the PI3 kinase (PI3K) inhibitor LY294002 markedly suppresses granzyme B expression |
707882 |
3.4.21.79 | up |
expression of granzyme B is higher in patients with Bronchiolitis obliterans syndrome than in patients with acute lung transplant rejection |
708189 |
3.4.21.79 | up |
expression of GrB mRNA is upregulated in active lesions of multiple sclerosis patients and in activated T cells |
717943 |
3.4.21.79 | up |
extracellular levels of the enzyme are elevated in the bodily fluids in chronic inflammatory diseases such as atherosclerosis and rheumatoid arthritis |
732687 |
3.4.21.79 | up |
GrB expression in plasmacytoid dendritic cells is strictly regulated on a transcriptional level involving Janus kinase 1 (JAK1), signal transducer and activator of transcription 3 (STAT3), and STAT5. Interleukin-3 (IL-3), secreted by activated T cells, plays a central role for GrB induction |
707852 |
3.4.21.79 | up |
GrB in urothelial cancer tissues is concentrated at the cancer invasion front and is expressed in neoplastic cells undergoing epithelial-mesenchymal transition, a key event in carcinoma invasion |
708765 |
3.4.21.79 | up |
IL-21 directly induces GzmB expression and secretion by CD51 B cells |
708381 |
3.4.21.79 | up |
in blood, bronchoalveolar lavage (BAL) and large airway brushing expression of granzyme B is significantly increased in lung transplant patients |
708189 |