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Results 1 - 5 of 5
EC Number Expression Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.54down capsaicin treatment overnight downregulates NAPE-PLD expression in capsaicin-sensitive cells by 70% at 0.01 mM 710115
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.54down ethanol downregulates microglial NAPE-PLD expression by activating cAMP/PKA and ERK1/2 750480
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.54down the pro-inflammatory bacterial endotoxin, lipopolysaccharide, decreases palmitoylethanolamide biosynthesis in RAW264.7 macrophages by suppressing the transcription of NAPE-PLD, which catalyzes the production of palmitoylethanolamide and other lipid amides. Liopolysaccharide treatment reduces acetylation of histone proteins bound to the NAPE-PLD promoter, an effect that is blocked by the histone deacetylase inhibitor richostatin A. The transcription factor Sp1 is involved in regulating baseline NAPE-PLD expression, but not in the transcriptional suppression induced by lipopolysaccharide. The down-regulation of NAPE-PLD expression may be functionally important because mutant NAPE-PLD-null mice, in which this regulatory process is defective, are unable to mount a normal inflammatory reaction in response to carrageenan 710010
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.54more Nape-pld is regulated by ovarian steroid hormones via their nuclear receptors 708985
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.54more the enzyme appears to be constitutively active 708079
Results 1 - 5 of 5