   3.1.13.4 | up |
the expression of several deadenylases is altered in squamous cell lung cancer, SCC. Quantitative real-time PCR shows that four deadenylases, PARN, CNOT6, CNOT7 and NOC, are differentially expressed in SCC clinical samples. PARN overexpression correlates with younger patient age and CNOT6 overexpression with non-metastatic tumors. Kaplan-Meier analysis suggests that increased levels of PARN and NOC correlate with significantly increased survival. The gene expression deregulation is functionally enriched for gene ontologies related to cell adhesion, cell junction, muscle contraction and metabolism |
751545 |
