EC Number   |
Expression |
Reference |
|---|
   2.3.1.85 | down |
(10E,12Z)-octadec-10,12-dienoic acid downregulates FAS expression in a concnetration-dependent manner, while (9Z,11E)-octadec-9,11-dienoic acid has no effect. (10E,12Z)-octadec-10,12-dienoic acid at 0.05 mM decreases FAS expression in MCF-7 cells by 52%, at 0.1 mM (10E,12Z)-octadec-10,12-dienoic acid, FAS protein is downregulated in MCF-7 (80%), LnCaP (27%), and HT-29 (61%) cells |
705999 |
| 2.3.1.85 | down |
C75 downregulates FASN mRNA in A2780 with an IC50 after 3d of 0.00525 mg/ml and an IT50 (time required for 50% inhibition) at 0.007 mg/ml of 21.5 h. This corresponds with FASN protein downregulation (IC50 = 0.00415 mg/ml), although the dynamics are slower (IT50 = 40 h). Pelitinib, given for 3d, abrogates FASN mRNA and protein in A-2780 cellsat doses as low as 0.003 mM |
702058 |
| 2.3.1.85 | down |
FAS expression is reduced by 25% in Ki-ras-induced actin-interacting protein-deficient liver |
706418 |
| 2.3.1.85 | down |
isoleucine, whey, leucine, valine, skim milk, and casein downregulate the expression of fatty acid synthase in a concentration-dependent manner, a plateau is reached at 1.0% (w/v) skim milk and casein corresponding to about 40% inhibition of FAS expression, whey leads to 54% inhibition of FAS expression at 2.0%(w/v) |
706003 |
| 2.3.1.85 | down |
mithramycin inhibits FAS expression, transfection of transcription factor Sp1 siRNA suppresses FAS expression |
704079 |
| 2.3.1.85 | down |
oleic acid and Tween 80 downregulate the expression of the fatty acid synthase while myristic acid, stearic acid, and Tween 40 do not |
706450 |
| 2.3.1.85 | more |
transcription factor Sp3 and Sp4 siRNAs do not affect FAS expression |
704079 |
| 2.3.1.85 | up |
17beta-estradiol increases FAS expression, estrogen induces FAS expression |
704079 |
| 2.3.1.85 | up |
expression of Fas1 and Fas2 is significantly elevated by the presence of glucose |
706450 |
| 2.3.1.85 | up |
fatty acid synthase is overexpressed in ovarian cancer |
702058 |
