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EC Number	Expression	Commentary	Reference
1.21.1.1	down	the enzyme is suppressed in liver and kidney by iodine intake. Excess iodine decreases the expression of thyroidal enzyme	-, 733459
1.21.1.1	more	study on enzyme expression in thyroid pathology. The highest DEHAL1 mRNA levels are found in Graves' disease thyroids, while downregulation of DEHAL1 and DEHAL1B mRNA occurrs in papillary thyroid carcinomas and anaplastic thyroid carcinomas. DEHAL1 protein is overexpressed in toxic thyroid nodules and Graves' disease thyroids with predominant apical staining in all samples. A weaker and patchy staining pattern is found in benign cold thyroid nodules and normal thyroids. In differentiated thyroid cancers such as follicular thyroid carcinomas and papillary thyroid carcinomas, a diffuse cytoplasmic DEHAL1 expression is found. In partially differentiated thyroid cancers and anaplastic thyroid carcinomas, DEHAL1 expression is faint or absent	703541
1.21.1.1	up	DEHAL12 is upregulated by cAMP	703608
1.21.1.1	up	iodine deficiency results in an increased enzyme expression in thyroid	-, 733459

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Release 2023.1 (January 2023)