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PlOvoA embryo expression significantly increases at the pluteus stage and is upregulated by metals (Cd2+ and Mn2+) at concentrations mimicking polluted sea-water and by cyclic toxic algal blooms, leading to ovothiol biosynthesis. In silico analysis of the PlOvoA upstream region reveals metal and stress responsive elements. PlOvoA expression profile and response to environmental stress conditions, overview. A significant increase of PlOvoA mRNA is observed at the swimming blastula stage after exposure to 0.001-0.005 mM Cd2+, whereas at the early blastula and prism stages, the gene transcription is unaffected. On the contrary, at the pluteus stage PlOvoA mRNA is strongly down-regulated after exposure to 0.005-0.010 mM Cd2+. In the presence of Mn2+, the relative expression ratio of PlOvoA at the swimming blastula stage is close to the minimum value considered significant. No appreciable gene regulation is observed in other developmental stages |
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