EC Number   |
Expression |
Reference |
|---|
    1.14.14.139 | down |
CYP8B1 mRNA levels show a diurnal rhythm, decrease during the day and reaching the lowest levels 2 h into the dark cycle |
727973 |
| 1.14.14.139 | down |
in mice deficient for liver receptor homolog LRH-1, basal CYP8B1 mRNA levels are significantly decreased. CYP8B1 repression by farnesoid X receptor FXR is intact in mice deficient for LRH-1 in hepatocytes |
688997 |
| 1.14.14.139 | down |
neonatal dexamethasone administration disturbs development of gene expression pattern into adulthood, the ratio of Cyp7a1/Cyp8b1 mRNA level, which is markedly increased at 4 weeks of age in the control group, shows a delayed increase at 8 weeks of age in the dexamethasone-treated animals |
700579 |
| 1.14.14.139 | up |
adenovirus-mediated gene transduction of retinoic acid-related orphan receptor alpha to mice strongly induces CYP8B1 expression (2.5fold) |
727973 |
| 1.14.14.139 | up |
dexamethasone administration results in significantly increased hepatic gene expression of Cyp8B1 in 2 days old rats compared with age-matched controls. In control animals, hepatic Cyp8b1 gene expression increases from 4 weeks onward and reaches to its maximal level at about 24 weeks of age |
700579 |
| 1.14.14.139 | up |
dexomethasone acutely induces hepatic mRNA levels of cholesterol 7alpha-hydrol Cyp6a1, cholesterol 27-hydrolase Cyp27, and in particular sterol 12alpha-hydrolase Cyp8b1. Neonatal dexomethasone administration leads to increased biliary lipid secretion, decreased Cyp8b1 mRNA expression and a 3fold higher Cyp7a1/Cyp8b1 mRNA ratio in rats at week 8 |
700579 |
