EC Number   |
Expression |
Reference |
|---|
   3.4.22.53 | down |
0.1 mM indomethacin and 0.1 mM NS-398 decrease expression of calpain 2 in total membrane fractions and in plasma membranes by 70%, while 0.001 mM SC-560 decreases expression of calpain 2 in total membrane fractions and in plasma membranes by 30% |
717669 |
| 3.4.22.53 | down |
a 6-day treatment with siRNA results in an about 60% reduction of calpain 2 protein levels in R1 cells |
709126 |
| 3.4.22.53 | up |
a heat stress stimulus induces massive germ cells apoptosis, which is associated with an increase in the levels of mRNA encoding calpain 2 |
709241 |
| 3.4.22.53 | up |
brain-derived neurotrophic factor and epidermal growth factor activate neuronal m-calpain via mitogen-activated protein kinase-dependent phosphorylation |
709641 |
| 3.4.22.53 | up |
calpain 2 expression levels increase throughout stem cell differentiation |
732688 |
| 3.4.22.53 | up |
calpain 2 is upregulated in mouse pancreas exposed to caerulein for 12 h |
707385 |
| 3.4.22.53 | up |
calpain activation occurs during reperfusion, but only after intracellular pH normalization, and is not prevented by inhibiting its translocation during ischemia with methyl-beta-cyclodextrin |
709566 |
| 3.4.22.53 | up |
endoplasmic reticulum stress stimulates calpain II activation, interleukin-13 enhances endoplasmic reticulum stress-regulated calpain activation and calpain-II expression in lipopolysaccaride-activated microglia |
708062 |
| 3.4.22.53 | up |
incubation of human retinal microvascular endothelial cells with vascular endothelial growth factor results in 1.6fold increased activity of calpain 2 at 24 h |
709652 |
| 3.4.22.53 | down |
inhibition of MEK1/2 using PD98059 reduces the expression of calpain-2 |
707902 |
