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interleukin-1 can potently downregulate mRNA and protein levels of LRAT and act as injury signal resulting in mobilization of retinyl esters in primary rat hepatic stellate cells. Secreted factors from Kupffer cells are able to suppress LRAT expression in hepatic stellate cells, which is neutralized by interleukin-1 receptor antagonist. The regulation is likely at transcriptional level. Interleukin-1 fails to downregulate recombinant LRAT protein expressed in the cells by adenovirus, while transcription of endogenous LRAT is promptly decreased. Interleukin-1 is a key mediator to down-regulate LRAT in liver injury
expression of LRAT and RPE65 can be modulated by retinoids
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