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a SF-1 binding region is located within intron 2 of the human FDXR gene. FDXR transcription is activated through the SF-1 binding site within intron 2. Endogenous SF-1 knockdown in human adrenocortical H295R and KGN cells decreased FDXR expression. In H295R cells, strong binding of two histone markers of active enhancers, histones H3K27ac and H3K4me2, is detected near the SF-1 binding site within intron 2. The binding of these histone markers is decreased concurrent with SF-1 knockdown in H295R cells
as compared to ovary adrenodoxin reductase concentration increases at least 50fold in corpora lutea
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