EC Number   |
BRENDA No. |
Title |
Journal |
Volume |
Pages |
Year |
Organism |
PubMed ID |
|---|
   3.4.23.45 | 754489 |
A comparative molecular dynamics study on BACE1 and BACE2 flap flexibility |
J. Recept. Signal Transduct. Res. |
36 |
505-514 |
2016 |
Homo sapiens |
26804314 |
| 3.4.23.45 | 754574 |
BACE2 distribution in major brain cell types and identification of novel substrates |
Life Sci. Alliance |
1 |
e201800026 |
2018 |
Mus musculus |
30456346 |
| 3.4.23.45 | 754563 |
BACE2, a conditional beta-secretase, contributes to Alzheimer's disease pathogenesis |
JCI Insight |
4 |
e123431 |
2019 |
Mus musculus |
30626751 |
| 3.4.23.45 | 753256 |
Design of potent and highly selective inhibitors for human beta-secretase 2 (memapsin 1), a target for type 2 diabetes |
Chem. Sci. |
7 |
3117-3122 |
2016 |
Homo sapiens |
27347366 |
| 3.4.23.45 | 753281 |
Highly selective and potent human beta-secretase 2 (BACE2) inhibitors against type 2 diabetes design, synthesis, X-ray structure and structure-activity relationship studies |
ChemMedChem |
14 |
545-560 |
2019 |
Homo sapiens |
30637955 |
| 3.4.23.45 | 754403 |
Structure-based design of selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors targeting the flap to gain selectivity over BACE2 |
J. Med. Chem. |
62 |
5080-5095 |
2019 |
Homo sapiens |
31021626 |
| 3.4.23.45 | 638900 |
A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase |
Cytogenet. Cell Genet. |
89 |
177-184 |
2000 |
Homo sapiens |
10965118 |
| 3.4.23.45 | 638895 |
A non-amyloidogenic function of BACE-2 in the secretory pathway |
J. Neurochem. |
81 |
1011-1020 |
2002 |
Homo sapiens |
12065613 |
| 3.4.23.45 | 683469 |
Altered beta-secretase enzyme kinetics and levels of both BACE1 and BACE2 in the Alzheimers disease brain |
FEBS Lett. |
580 |
6550-6560 |
2006 |
Homo sapiens |
17113083 |
| 3.4.23.45 | 683469 |
Altered beta-secretase enzyme kinetics and levels of both BACE1 and BACE2 in the Alzheimers disease brain |
FEBS Lett. |
580 |
6550-6560 |
2006 |
Rattus norvegicus |
17113083 |
