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EC Number BRENDA No. Title Journal Volume Pages Year Organism PubMed ID
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.57755529 Caspase-4 disaggregates lipopolysaccharide micelles via LPS-CARD interaction Sci. Rep. 9 826 2019 Homo sapiens 30696842
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.57753479 Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells Eur. J. Immunol. 45 2911-2917 2015 Homo sapiens 26174085
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.57754835 Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes Nat. Commun. 6 8761 2015 Homo sapiens 26508369
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.57754851 Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11 Nat. Commun. 9 242 2018 Homo sapiens 29339744
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.57755248 Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens Proc. Natl. Acad. Sci. USA 112 6688-6693 2015 Homo sapiens 25964352
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.57647429 A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis J. Biol. Chem. 272 17907-17911 1997 Homo sapiens 9218414
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.57732274 A critical role for human caspase-4 in endotoxin sensitivity J. Immunol. 193 335-343 2014 Homo sapiens 24879791
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.57647729 A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells EMBO J. 14 1914-1922 1995 Homo sapiens 7743998
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.57699160 Assessment of caspase-4 released free AFC by RP-HPLC and fluorescence detection J. Chromatogr. B 874 111-114 2008 Homo sapiens 18824420
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.57695936 Benzene activates caspase-4 and -12 at the transcription level, without an association with apoptosis, in mouse bone marrow cells lacking the p53 gene Arch. Toxicol. 83 795-803 2009 Mus musculus 19326098
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