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Results 1 - 8 of 8
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EC Number Reaction Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 6.5.1.1(deoxyribonucleotide)n-3'-hydroxyl + 5'-(5'-diphosphoadenosine)-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP (1c) -
Display the word mapDisplay the reaction diagram Show all sequences 6.5.1.1ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate initial step in DNA ligation is the formation of a covalent enzyme-adenylate intermediate 1937
Display the word mapDisplay the reaction diagram Show all sequences 6.5.1.1ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate joining of single-stranded breaks in duplex DNA -
Display the word mapDisplay the reaction diagram Show all sequences 6.5.1.1ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate mechanism: 1. formation of a covalent enzyme-adenylate complex, the ATP is cleaved to AMP and diphosphate with adenylyl residue linked by a phosphoramidate bond to the epsilon-amino group of a specific lysine residue at the active site of the protein, 2. the activated AMP residue of the DNA ligase-adenylate intermediate is transferred to the 5'-phosphate terminus of a single strand break in double-stranded DNA to generate a covalent DNA-AMP complex with a 5'-5' phosphoanhydride bond, 3. in the final step of DNA ligation, unadenylated DNA ligase is required for the generation of a phosphodiester bond and catalyzes displacement of the AMP residue through attack by adjacent 3'-hydroxyl group of the adenylylated site 1906, 1907
Display the word mapDisplay the reaction diagram Show all sequences 6.5.1.1ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate overall reaction -
Display the word mapDisplay the reaction diagram Show all sequences 6.5.1.1ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate uni-uni uni-bi ping-pong mechanism. The order of substrate addition and product release is as follows: ATP, diphosphate, nicked DNA, sealed DNA, 5'-AMP 1929
Display the word mapDisplay the reaction diagram Show all sequences 6.5.1.1ATP + [DNA ligase]-L-lysine = [DNA ligase]-N6-(5'-adenylyl)-L-lysine + diphosphate (1a) -
Display the word mapDisplay the reaction diagram Show all sequences 6.5.1.1[DNA ligase]-N6-(5'-adenylyl)-L-lysine + 5'-phospho-(deoxyribonucleotide)m = 5'-(5'-diphosphoadenosine)-(deoxyribonucleotide)m + [DNA ligase]-L-lysine (1b) -
Results 1 - 8 of 8
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