EC Number   |
Reaction |
Reference |
|---|
    6.3.5.3 | ATP + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine + L-glutamate |
Gln adds first to the enzyme with ATP and 5'-phosphoribosylformylglycinamide adding randomly subsequently |
1666 |
| 6.3.5.3 | ATP + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine + L-glutamate |
Gln binds to the free enzyme and Glu is released before the addition of ATP. ADP is released, and phosphoribosyl-formylglycinamide then binds. The liberation of phosphate is rapid, and 5'-phosphoribosylformylglycinamidine is the last product released |
1668 |
| 6.3.5.3 | ATP + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine + L-glutamate |
ping-pong mechanism |
1667, 1668, 1669 |
| 6.3.5.3 | ATP + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine + L-glutamate |
substrates add sequentially to form a quarternary complex. Gln adds first with ATP and 5'-phosphoribosylformylglycinamide adding subsequently |
1665 |
