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Results 1 - 8 of 8
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EC Number Reaction Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 5.6.1.6ATP + H2O + closed Cl- channel = ADP + phosphate + open Cl- channel - -
Display the word mapDisplay the reaction diagram Show all sequences 5.6.1.6ATP + H2O + closed Cl- channel = ADP + phosphate + open Cl- channel asymmetric motion of the nucleotide binding domains 1 and 2 during channel gating. Opening of the channel is initiated by ATP at the nucleotide-binding domain 2 site, whereas separation of the nucleotide-binding domain dimer at the nucleotide-binding domain 1 site constitutes the rate-limiting step in channel closing 688124
Display the word mapDisplay the reaction diagram Show all sequences 5.6.1.6ATP + H2O + closed Cl- channel = ADP + phosphate + open Cl- channel ATP binding, conformational changes, and ATPase and channel activity reaction mechanism, overview 700618
Display the word mapDisplay the reaction diagram Show all sequences 5.6.1.6ATP + H2O + closed Cl- channel = ADP + phosphate + open Cl- channel regulation of CFTR activation by R domain phosphorylation followed by ATP binding at the nucleotide-binding domain-1 site enables the cycling mechanism to proceed. ATP catalysis at the catalytically active nucleotide?binding domain-2 is sufficient to drive the gating cycle, CFTR gating mechanism proceeds in 4 steps, detailed overview. The enzyme being a functional channel adapts the ATP switch gating mechanism designed for transporters, ATP Switch model analysis 733100
Display the word mapDisplay the reaction diagram Show all sequences 5.6.1.6ATP + H2O + closed Cl- channel = ADP + phosphate + open Cl- channel the conformation of nucleotide-binding domain 1 changes before that of nucleotide-binding domain 2 during channel opening. Nucleotide-binding domain dimerization does not proceed by a symmetric tweezer-like motion, but instead in an asymmetric fashion led by nucleotide-binding domain1 689759
Display the word mapDisplay the reaction diagram Show all sequences 5.6.1.6ATP + H2O + closed Cl- channel = ADP + phosphate + open Cl- channel the conformation of nucleotide-binding domain1 changes before that of nucleotide-binding domain 2 during channel opening. Nucleotide-binding domain dimerization does not proceed by a symmetric tweezer-like motion, but instead in an asymmetric fashion led by nucleotide-binding domain1 689759
Display the word mapDisplay the reaction diagram Show all sequences 5.6.1.6ATP + H2O + closed Cl- channel = ADP + phosphate + open Cl- channel the structure of the CFTR channel pore is highly asymmetric with a narrower extracellular entrance and a dilating conformational change of the extracellular entrance is associated with the channel transition to a nonhydrolytic, locked-open state 720313
Display the word mapDisplay the reaction diagram Show all sequences 5.6.1.6ATP + H2O + closed Cl- channel = ADP + phosphate + open Cl- channel upon channel opening, the wide cytoplasmic vestibule tightens and the pore-lining TM12 rotates along its helical axis 720151
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