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Results 1 - 6 of 6
EC Number Reaction Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 5.4.99.25tRNA uridine55 = tRNA pseudouridine55 - -
Display the word mapDisplay the reaction diagram Show all sequences 5.4.99.25tRNA uridine55 = tRNA pseudouridine55 RluA does not require thiol(ate) groups to effect catalysis 648867
Display the word mapDisplay the reaction diagram Show all sequences 5.4.99.25tRNA uridine55 = tRNA pseudouridine55 the mechanism of uridine55 recognition by Cbf5 and the bacterial TruB are different 706710
Display the word mapDisplay the reaction diagram Show all sequences 5.4.99.25tRNA uridine55 = tRNA pseudouridine55 the side chain of the conserved tyrosine in the four families of pseudouridine synthases (TruA, TruB, RsuA and RluA) plays a dual role within the active site, maintaining the structural integrity of the active site through its hydrophobic phenyl ring and acting as a general base through its OH group for the proton abstraction required in the last step of pseudouridine synthase-catalyzed formation of pseudouridine 661179
Display the word mapDisplay the reaction diagram Show all sequences 5.4.99.25tRNA uridine55 = tRNA pseudouridine55 this enzyme recognizes the preformed three-dimensional structure of the T loop primarily through shape complementarity. It accesses its substrate uridyl residue by flipping out the nucleotide and disrupts the tertiary structure of tRNA 650781
Display the word mapDisplay the reaction diagram Show all sequences 5.4.99.25tRNA uridine55 = tRNA pseudouridine55 this enzyme undergoes significant conformational changes on binding to its substrate. These conformational changes include the ordering of the thumb loop, which binds right into the RNA hairpin loop, and a 10° hinge movement of the C-terminal domain. TruB recognizes its RNA substrate through a combination of rigid docking and induced fit, with TruB first rigidly binding to its target and then maximizing the interaction by induced fit 653587
Results 1 - 6 of 6