5.4.2.10 | alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate |
The enzyme is involved in the pathway for bacterial cell-wall peptidoglycan and lipopolysaccharide biosynthesis, being an essential step in the pathway for UDP-N-acetylglucosamine biosynthesis. The enzyme from E. coli is activated by phosphorylation and can be autophosphorylated in vitro by glucosamine 1,6-bisphosphate, which is an intermediate in the reaction, glucose 1,6-bisphosphate or ATP. It can also catalyse the interconversion of glucose 1-phosphate and glucose 6-phosphate, although at a much lower rate |
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