EC Number |
Reaction |
Reference |
---|
5.1.3.19 | Chondroitin D-glucuronate = dermatan L-iduronate |
after inversion, a hydrogen from the medium is reinserted into the uronosyl residue |
2299 |
5.1.3.19 | Chondroitin D-glucuronate = dermatan L-iduronate |
His-450 functions as a general base abstracting the C5 proton from glucuronic acid. Subsequent cleavage of the glycosidic linkage by Tyr-261 generates a 4,5-unsaturated hexuronic intermediate, which is protonated at the C5 carbon by His-205 from the side of the sugar plane opposite to the side of previous proton abstraction. Concomitant recreation of the glycosidic linkage ends the reaction, generating iduronic acid, proposed molecular mechanism of epimerization, overview |
704498 |
5.1.3.19 | Chondroitin D-glucuronate = dermatan L-iduronate |
processive reducing to non-reducing end mode of action of DS-epi1, in silico modeling of site-specific information |
747527 |
5.1.3.19 | Chondroitin D-glucuronate = dermatan L-iduronate |
two-base reaction mechanism, involving a monoprotic L-iso-specific base and a polyprotic D-gluco-specific base |
2304 |