EC Number |
Reaction |
Reference |
---|
4.2.1.96 | 4a-hydroxytetrahydrobiopterin = 6,7-dihydrobiopterin + H2O |
- |
- |
4.2.1.96 | 4a-hydroxytetrahydrobiopterin = 6,7-dihydrobiopterin + H2O |
His61 and His79 act as acid catalysts for the stereospecific elimination of the 4a(R)- and 4a(S)-hydroxyl groups, respectively. The role of His62 is primarily binding substrate with additional component of base catalysis |
5940 |
4.2.1.96 | 4a-hydroxytetrahydrobiopterin = 6,7-dihydrobiopterin + H2O |
mechanism |
5929 |
4.2.1.96 | 4a-hydroxytetrahydrobiopterin = 6,7-dihydrobiopterin + H2O |
the mechanism of dehydration involves base catalysis at the N(5)-H group of the substrate by His61 |
5933 |