EC Number   |
Reaction |
Reference |
|---|
    4.1.99.17 | 5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO |
- |
- |
| 4.1.99.17 | 5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO |
mechanistic analysis |
713759 |
| 4.1.99.17 | 5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO |
radical reaction mechanism, overview |
727883 |
| 4.1.99.17 | 5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO |
the enzyme uses a [4Fe-4S] cluster to reductively cleave AdoMet to methionine and a 5'-deoxyadenosyl radical that initiates catalysis |
727960 |
