EC Number |
Reaction |
Reference |
---|
4.1.3.4 | (S)-3-Hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate |
C237 is crucial for catalysis |
5366 |
4.1.3.4 | (S)-3-Hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate |
enzyme is stereospecific and proceeds with inversion of configuration |
5365 |
4.1.3.4 | (S)-3-Hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate |
identification of functionally important S69 |
5372 |
4.1.3.4 | (S)-3-Hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate |
identification of reactive cysteines, possibly regulatory mechanism via thiol/disulfide exchange |
5370, 5373 |