EC Number   |
Reaction |
Reference |
|---|
    4.1.1.23 | orotidine 5'-phosphate = UMP + CO2 |
catalysis by OMPDC is due to stabilization of the decarboxylation transition state by interactions with the protein catalyst leading to a 1023-fold rate acceleration. The falloff in the second-order rate constants for OMPDC-catalyzed decarboxylation observed upon the truncation of the phosphodianion and the ribosyl phosphate from the substrate orotidine 5'-phosphate (OMP), catalytic mechanism, detailed overview. Interaction between the side chains of Ser154 and Gln215 wild-type ScOMPDC is required to hold the amide side chain in a position to interact with the substrate phosphodianion. The dianion binding interactions with Gln215, Tyr217, and Arg235 serve the exclusive function of activating OMPDC for catalysis at the pyrimidine binding site |
-, 746572 |
| 4.1.1.23 | orotidine 5'-phosphate = UMP + CO2 |
catalytic mechanism |
-, 649973, 650513, 653647 |
| 4.1.1.23 | orotidine 5'-phosphate = UMP + CO2 |
catalytic mechanism with freely reversible binding, a very limited contribution to the overall rate is made by chemical steps preceding decarboxylation |
4181 |
| 4.1.1.23 | orotidine 5'-phosphate = UMP + CO2 |
decarboxylation mechanism, substrate recognition mechanism with dynamic structural changes, as well as the rearrangement of the hydrogen bond array at the active site |
680570 |
| 4.1.1.23 | orotidine 5'-phosphate = UMP + CO2 |
direct decarboxylation mechanism, modeling with 6-carbanion derivatives of uracil analogues, overview |
682233 |
| 4.1.1.23 | orotidine 5'-phosphate = UMP + CO2 |
kinetic mechanism |
649921 |
| 4.1.1.23 | orotidine 5'-phosphate = UMP + CO2 |
mechanism |
-, 4186, 649331, 649542, 649975, 650143, 650145, 652109 |
| 4.1.1.23 | orotidine 5'-phosphate = UMP + CO2 |
mechanism, thermodynamic data |
650934, 651572 |
| 4.1.1.23 | orotidine 5'-phosphate = UMP + CO2 |
nitrogen ylide mechanism |
-, 4182 |
| 4.1.1.23 | orotidine 5'-phosphate = UMP + CO2 |
reaction mechanism |
649479, 653646, 678241 |
