3.6.1.40 | guanosine 5'-triphosphate 3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate |
the hydrolytic base is E119, the dual specificity typical for the exopolyphosphatase/guanosine pentaphosphate phosphohydrolase protein family is due to a common active site for guanosine pentaphosphate and polyphosphate hydrolysis, R22 and R267, residing in different domains, are crucial for guanosine pentaphosphate specificity as they interact with the unique 3'-ribose phosphorylation |
688392 |