EC Number   |
Reaction |
Reference |
|---|
    3.5.4.25 | GTP + 4 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + 2 phosphate |
- |
- |
| 3.5.4.25 | GTP + 4 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + 2 phosphate |
2 C-N bonds are hydrolysed, releasing formate, with simultaneous removal of the terminal diphosphate, reaction mechanism |
656006 |
| 3.5.4.25 | GTP + 4 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + 2 phosphate |
ordered reaction mechanism, in which the hydrolytic release of diphosphate preceeds the hydrolytic attack of the imidazole ring, ring opening and formate release are dependent on zinc bound to the active site, overview |
655443 |
| 3.5.4.25 | GTP + 4 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + 2 phosphate |
reaction mechanism |
656029 |
| 3.5.4.25 | GTP + 4 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + 2 phosphate |
RibA is a bifunctional enzyme possessing 3,4-dihydroxy-2-butanone 4-phosphate synthase activity, EC 4.1.99.12, located in the N-terminal half of the protein and GTP cyclohydrolase II activity of the C-terminal domain, overview |
675226 |
