EC Number |
Reaction |
Reference |
---|
3.5.1.23 | a ceramide + H2O = a carboxylate + sphingosine |
- |
- |
3.5.1.23 | a ceramide + H2O = a carboxylate + sphingosine |
catalytic mechanism |
667523 |
3.5.1.23 | a ceramide + H2O = a carboxylate + sphingosine |
kinetic mechanism |
655998 |
3.5.1.23 | a ceramide + H2O = a carboxylate + sphingosine |
neutral CDase contains a zinc ion in the active site that functions as a catalytic center, and the hydrolysis of the N-acyl linkage in ceramide proceeds through a mechanism that is similar to that described for zinc-dependent carboxypeptidase, reaction mechanism, overview |
733408 |
3.5.1.23 | a ceramide + H2O = a carboxylate + sphingosine |
the enzyme has a catalytic residue Ser354 within a very highly conserved hexapeptide sequence GDVSPN in the middle of a larger conserved sequence, namely NXGDVSPNXXGP/XXC, catalytic mechanism |
667523 |