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EC Number Reaction Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.5.1.11penicillin + H2O = a carboxylate + 6-aminopenicillanate - -
Display the word mapDisplay the reaction diagram Show all sequences 3.5.1.11penicillin + H2O = a carboxylate + 6-aminopenicillanate F24 in beta-subunit has a fixed position, whereas F146 of alpha-subunit acts as a flexible lid on the binding site 670745
Display the word mapDisplay the reaction diagram Show all sequences 3.5.1.11penicillin + H2O = a carboxylate + 6-aminopenicillanate structural model and catalytic mechanism, and energetics of the reaction, acylation is the rate-limiting step of hydrolysis. The collapse of the tetrahedral intermediate proceeds via synchronous bond breaking and formation, and the accumulation of charge on the amidic nitrogen due to the presence of a substituent is disfavored 711692
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